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White Paper: The Superiority of Quaternary Ammonium Compounds as Disinfectants in Animal Care Facilities Executive Summary In the realm of animal care facilities, maintaining a clean and pathogen ‐ free environment is paramount for the health and well ‐ being of both animals and humans. Quaternary Ammonium Compounds (Quats) have emerged as the disinfectant of choice, surpassing other types of disinfectants in efficacy, safety, and environmental compatibility. This white paper delineates the advantages of Quats, supported by scientific research and regulatory guidelines, making the case for their superiority over alternative disinfectant chemistries such as alcohols, chlorine, and hydrogen peroxides. Introduction Animal care facilities face unique challenges in disinfection practices, including the need for broad ‐ spectrum efficacy, safety for animals and humans, material compatibility, and environmental considerations. Quats, with their versatile properties, address these requirements more effectively than other disinfectants. This document explores the characteristics that make Quats an ideal choice for animal care settings, supported by qualified references. Quats vs. Other Disinfectants Broad ‐ Spectrum Efficacy Quats are renowned for their broad ‐ spectrum antimicrobial activity, effectively inactivating a wide range of pathogens, including bacteria, viruses, fungi, and protozoa. Unlike bleach (sodium hypochlorite), which can be highly corrosive and poses risks to animals if not thoroughly rinsed, Quats remain effective without damaging surfaces or posing significant health risks to animals.  Reference: Block, S. S. (2001). Disinfection, Sterilization, and Preservation . Philadelphia: Lippincott Williams & Wilkins. Safety Profile Quats offer a superior safety profile compared to other disinfectants. For instance, alcohols and hydrogen peroxides can be highly volatile and pose a fire risk, while also being potentially irritating to respiratory systems. Quats, however, are non ‐ toxic at recommended dilutions and do not volatilize, ensuring safety for use around animals and humans.  Reference: Rutala, W. A., Weber, D. J., & Healthcare Infection Control Practices Advisory Committee (HICPAC). (2019). Guideline for Disinfection and Sterilization in Healthcare Facilities . Material Compatibility Quats are less corrosive than chlorine ‐ based disinfectants and more stable than hydrogen peroxide, ensuring a longer shelf life and suitability for a wide range of materials, including

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